Institute of Nano Electronic Engineering
Universiti Malaysia Perlis
Knowledge sharing by Dr Nur Syakimah which was held on June 26, 2015 at Seminar Room Tun Mahathir, Seriab.
A total of 30 people took part in a presentation at this time, mostly consisting of students and research fellows.
Dr Nur Syakimah at this time was willing to share its findings with the title Gold nanoparticles-functionalized graphene oxide nanoribbons for enhanced performance of electrochemical based biosensors.
Abstract – The study demonstrates the development of a liquid-based gate-control silicon nanowire biosensor for detection of specific single-stranded DNA (ssDNA) molecules. The sensor was fabricated using conventional photolithography coupled with an inductively coupled plasma dry etching process. Prior to the application of DNA to the device, its linear response to pH was confirmed by serial dilution from pH 2 to pH14. Then, the sensor surface was silanized and directly aminated with (3-aminopropyl) triethoxysilane to create a molecular binding chemistry for biofunctionalization. The resulting Si‒O‒Si‒ components were functionalized with receptor ssDNA, which interacted with the targeted ssDNA to create a field across the silicon nanowire and increase the current. The sensor shows selectivity for the target ssDNA in a linear range from target ssDNA concentrations of 100 pM to 25 nM. With its excellent detection capabilities, this sensor platform is promising for detection of specific biomarkers and other targeted proteins.
Keywords – Nanowire biosensor, APTES, ssDNA, DNA, Photolithography, Liquid gate control
Corresponding Author: Uda Hashim
Corresponding Author’s Email: uda@unimap.edu.my
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