Archives for July 2019

Transformation of Smart Sensor Technology in Real World

July 30, 2019 By Editor

1-Day Seminar Talk entitled Transformation of Smart Sensor Technology in Real World was held in Bayview Beach Resort, Batu Ferringhi, Pulau Pinang, Malaysia on Tuesday, 23rd of July of 2019. This seminar was launched by Assoc. Prof. Dr. Ruslinda A. Rahim, Director of Institute Nano Electronic Engineering.

More than 46 participants came from Malaysia and Japan was attending this seminar to gain knowledges about new sensor technology. The list of Malaysian Universities participated in this seminar came from Universiti Malaysia Perlis (UniMAP), Universiti Sains Malaysia (USM), University Kebangsaan Malaysia (UKM), Universiti Kuala Lumpur (UniKL), Universiti Pertahanan Nasional Malaysia (UPNM), University Teknologi Malaysia (UTM), Universiti Teknologi PETRONAS (UTP), and Heriot-Watt University.

While the Japan participants came from Osaka University and Tokyo University of Agriculture and Technology. 1-day Seminar Transformation of Smart Sensor Technology in Real World is one of the platforms that can bring in expertise from outside and within Malaysia to see the prospect of sensors and then see the direction of sensor use in today’s world and Malaysia in particular.

Through this workshop, researchers in UniMAP are expected to maintain collaboration between universities within and outside to further enhance extensive sensor-based research. The list of speaker and their talk titles as listed below:

Speaker Session I
Speaker: Prof. Dr. Ravichandran Manickam, AIMST University, Kedah
Title: Biosensors for the infectious diseases

Speaker Session II
Speaker: Prof. Dr. Sandro Carrara (IEEE), École Polytechnique Fédérale De Lausanne, Switzerland
Title: Bio/Nano/CMOS interface for remote monitoring of Human Metabolism

Speaker Session III
Speaker: Prof. Dr. Paul C.-P. Chao, National Chiao Tung University
Title: A New Flexible Photoplethysmography (PPG) Sensor Patch for Stable, Continuous Blood Flow Volume and Pressures Measurement

Speaker Session IV
Speaker: Prof. Dr. Khairunisak Bt. Abdul Razak, Universiti Sains Malaysia
Title: Nanomaterials based sensors: biosensors and modified electrochemical sensors

Speaker Session V
Speaker: Prof. Dr. Uda Hashim, Deputy Vice Chancellor, UniMAP
Title: IOT Based Biosensor: Rapid Detection for Food Poisoning

ruslinda a rahim — Welcoming and opening speech by director of INEE, Assoc. Prof. Dr. Ruslinda.

Speaker Session I by Prof. Dr. Ravichandran Manickam from AIMST University.

Speaker Session II by Prof. Dr. Sandro Carrara.

Speaker Session III by Prof. Dr. Paul C.-P. Chao from National Chiao Tung University.

Speaker Session IV by Prof. Dr. Khairunisak Bt. Abdul Razak from Universiti Sains Malaysia.

Speaker Session V by Prof. Dr. Uda Hashim from UniMAP.

Complementation of ELISA and an Interdigitated Electrode Surface in Gold Nanoparticle Functionalization for Effective Detection of Human Blood Clotting Defects

July 29, 2019 By Editor

Abstract – Developing an enhanced diagnosis using biosensors is important for the treatment of patients before disease complications arise. Improving biosensors would enable the detection of various low-abundance disease biomarkers. Efficient immobilization of probes/receptors on the sensing surface is one of the efficient ways to enhance detection. Herein, we introduced the pre-alkaline sensing surface with amine functionalization for capturing gold nanoparticle (GNP) conjugated to human blood clotting factor IX (FIX), and we demonstrated the excellent performance of the strategy. We have chosen the enzyme-linked immunosorbent assay (ELISA) and the interdigitated electrode (IDE), which are widely used, to demonstrate our method. The optimal amount for silanization has been found to be 2.5%, and 15-nm-sized GNPs are ideal and characterized. The limit of FIX detection was attained with ELISA at 100 pM with the premixed GNPs and FIX, which shows 60-fold improvement in sensitivity without biofouling, as compared to the conventional ELISA. Further, FIX was detected with higher specificity in human serum at a 1:1280 dilution, which is equivalent to 120 pM FIX. These results were complemented by the analysis on IDE, where improved detection at 25 pM was achieved, and FIX was detected in human serum at the dilution of 1:640. These optimized surfaces are useful for improving the detection of different diseases on varied sensing surfaces.

Corresponding Author: Assoc. Prof. Dr. Subash C B Gopinath
Corresponding Author’s Email: subash@unimap.edu.my

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Multidimensional (0D-3D) nanostructures for lung cancer biomarker analysis: Comprehensive assessment on current diagnostics

July 8, 2019 By Editor

Abstract – The pragmatic outcome of a lung cancer diagnosis is closely interrelated in reducing the number of fatal death caused by the world’s top cancerous disease. Regardless of the advancement made in understanding lung tumor, and its multimodal treatment, in general the percentage of survival remain low. Late diagnosis of a cancerous cell in patients is the major hurdle for the above circumstances. In the new era of a lung cancer diagnosis with low cost, portable and non-invasive clinical sampling, nanotechnology is at its inflection point where current researches focus on the implementation of biosensor conjugated nanomaterials for the generation of the ideal sensing. The present review encloses the superiority of nanomaterials from zero to three-dimensional nanostructures in its discrete and nanocomposites nanotopography on sensing lung cancer biomarkers. Recent researches conducted on definitive nanomaterials and nanocomposites at multiple dimension with distinctive physiochemical property were focused to subside the cases associated with lung cancer through the development of novel biosensors. The hurdles encountered in the recent research and future preference with prognostic clinical lung cancer diagnosis using multidimensional nanomaterials and its composites are presented.

Corresponding Author: Assoc. Prof. Dr. Subash C B Gopinath
Corresponding Author’s Email: subash@unimap.edu.my

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