Design and fabrication of PDMS microfluidics device for rapid and label-free DNA detection
Abstract – Microfluidics explores the manipulation of fluid in small volume, a multidisciplinary field is imperative for DNA extraction. This study offers a simple yet substantial methodology for the fabrication of microfluidics structure-based polydimethylsiloxane (PDMS) biopolymer on a glass substrate with SU-8 photoresist for label-free detection of pathogenic genomic DNA. Two microfluidics designs for DNA detection were based on AutoCAD software, both contain two inlets and one outlet, with dimensions of 28 mm wide, and 18 mm long, and total surface area of 504 mm2. The designs were patterned in such particular sizes and dimensions to test fluid delivery and enhancement in biochemical processes in DNA extraction, while maintaining economical values as a disposable chip. Both microfluidics devices showed no leakage during fluid delivery, have heights of 97.97 and 103.44 μm, and surface roughness of 0.15 and 0.07 μm, respectively. DNA extraction from pathogenic fungus Ganoderma boninense was run on PDMS microfluidic device and UV–Vis analysis confirmed successful extraction with peaks found at 260–280 nm. Current–voltage (I–V) measurement confirmed the accuracy of microfluidic device for the specific pathogen with both real and synthetic samples of G. boninense illustrating the similar graph values of only 0.000005 A difference at 1.0 V after hybridization.
Corresponding Author: Prof. Dr. Uda Hashim
Corresponding Author’s Email: uda@unimap.edu.my
Download Abstract: PDF
CSR Programme: Sharing knowledge about proposal, thesis writing and research project with MRSM Langkawi student
On the previous March 5, 2020, Dr. Nor Azizah binti Parmin from Institute of Nano Electronic Engineering (INEE) was invited as a speaker by MRSM Langkawi to share her knowledge in proposal and thesis writing to MRSM teachers and students. She also shares her research innovation project in this talk programme.
More than 200 students Form 3, 4, and 5 with their teachers were involved in this programme. This programme was led by Assoc. Prof. Dr. Mohd Rashidi Che Beson from School of Computer & Communication Engineering, Universiti Malaysia Perlis (UniMAP). Besides Dr. Nor Azizah Parmin, Dr. Mohamad Nur Khairul Hafizi Rohani from School of Electrical System Engineering, Universiti Malaysia Perlis (UniMAP) also invited by MRSM Langkawi as a speaker.
We hope that this sharing knowledge programme will provide students with valuable experience and knowledge as well as interest in science and technology.
INEE-MRSM Langkawi Collaboration Meeting for Tunas Scientist International Level
On February 27, 2020, Institute of Nano Electronic Engineering (INEE) was received a visit from MRSM Langkawi for the collaboration and discussion about innovation project. The project will be presented for Tunas Scientist International Level at MRSM Sungai Besar, Selangor on March 1, 2020. In this visit, INEE also provided and encouraging clear picture to MRSM Langkawi on the state of Laboratory and research facilities available at INEE.
UniMAP Advisor: Prof. Ts. Dr. Uda bin Hashim and Dr. Nor Azizah binti Parmin
MRSM Langkawi: Cikgu Zaiton binti Abdullah and Farah Wahida binti Roslee (student)
10th Creation, Innovation, Technology & Research Exposition (CITREx 2020)
Universiti Malaysia Pahang (UMP) has organized the 10th Creation, Innovation, Technology & Research Exposition (CITREx 2020) innovation program held on February 12 and 13, 2020 at the Sports Complex, Gambang Campus, UMP.
A total of 402 participating research and innovation products from various public and private universities participated in CITREx 2020. Universiti Malaysia Perlis through the UniMAP Intellectual Property Commercialization Center (CIPC) submitted 4 research products to CITREx 2020.
Thankfully, UniMAP has achieved 100% success by earning two gold and two silver medals at this time. Here’s a list of researchers who received medals:
Gold Medal
- Dr Mohd Aminuddin Bin Jamlos (FTK): BVD-APP: Blood Vessel Detection Monitoring System for Diabetic Retinopathy Diagnosis
- Dr Nor Azizah Bt Parmin (INEE): MicroRNA (miRNA) Biosensor Diagnostic System for Early Detection Ovarian Cancer
Silver Medal
- Ts. Dr Wan Azani Wan Mustafa (FTK): A Smart Monitoring system For Cervical Cancer Classification Based on Nucleus Analysis
- Rosfatihah Bt Roslim (INSAT): Pre-Commercialisation Of Nutritional Exotic Fruit – Based Sambal
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