Institute of Nano Electronic Engineering

Universiti Malaysia Perlis

  • Facebook
  • Instagram
  • Twitter
  • YouTube
  • About Us
    • Background
    • Mission and Vision
    • Organization
    • Client’s Charter
    • Corporate Video
    • Our Expertise
    • Acknowledgement
  • Research
    • Research Facilities
    • Research Activities
      • Research Focus
      • Research Projects
        • Products
      • Postgraduate
        • Current Students
        • Alumni
      • Collaborations
  • Publications
    • Scoreboard
  • Contact Us
    • Staff Directory
    • Feedback
  • Gallery
    • Video
    • Audio
  • Download
    • Archive
    • Publications
    • Forms
    • OBE Awareness
    • Reports
  • Quick Links
    • Support Links
    • FAQ
    • Sitemap
    • Faculty
    • Other Departments
    • Events
You are here: Home / Publications / Substrate-gate coupling in ZnO-FET biosensor for cardiac troponin I detection

Substrate-gate coupling in ZnO-FET biosensor for cardiac troponin I detection

March 17, 2017 By Editor

Abstract – Currently, field-effect transistor (FET)-based biosensors have been implemented in several portable sensors with the ultimate application in point-of-care testing (POCT). In this paper, we have designed substrate-gate coupling in FET-based biosensor for the detection of cardiac troponin I (cTnI) biomarker. In the device structure, zinc oxide nanoparticles (ZnO-NPs) thin film were deposited through sol-gel and spin coating techniques on the channel. The p-type silicon was used as a substrate, while ZnO is an n-type nanomaterial, thus creates p-n-p junction between source, channel, and drain. The deposited thin films exhibited hexagonal wurtzite phase of ZnO, suitable for biomolecular interaction as revealed in X-ray diffraction (XRD) analysis. The surface of the thin film was then functionalized with 3-aminopropyltriethoxysilane (APTES), followed by glutaraldehyde (GA) as a bi-functional linker to immobilize the cTnI monoclonal antibody (MAb-cTnI) as bio-receptor for capturing cTnI biomarker and proven by the Fourier transform-infrared (FT-IR) spectra. Lastly, we demonstrated a new strategy, the integration of FET-based biosensors with substrate-gate showed differences between before (immobilization) and after cTnI target biomarker interaction by significant changes in drain current (ID) and change of threshold voltage (VT), which improved the sensitive detection, with the limit of detection down to 3.24 pg/ml.

Keywords – Biosensor, Cardiac troponin I, Electrical-based, Field-effect transistor, Substrate-gate coupling, Zinc oxide nanoparticles

Corresponding Author: Uda Hashim
Corresponding Author’s Email: uda@unimap.edu.my

Full text: PDF

Share this:

  • Click to share on Facebook (Opens in new window)
  • Click to share on Twitter (Opens in new window)
  • Click to share on Pinterest (Opens in new window)
  • Click to email a link to a friend (Opens in new window)
  • More
  • Click to share on Reddit (Opens in new window)
  • Click to share on LinkedIn (Opens in new window)
  • Click to share on WhatsApp (Opens in new window)
  • Click to print (Opens in new window)
  • Click to share on Telegram (Opens in new window)

Filed Under: Publications Tagged With: Biosensor, Cardiac troponin I, Electrical-based, Field-effect transistor, Substrate-gate coupling, Zinc oxide nanoparticles

NEWS @ INEE

  • Postgraduate Studies Opportunity
  • Congratulations Prof. Ir. Dr. Mohd Khairuddin Md Arshad
  • Assoc. Prof. Ts. Dr. Muhammad Mahyiddin Ramli Appointed as New Director of INEE
  • Assoc. Prof. Ts. Dr. Foo Kai Loong Appointed as New Deputy Director of INEE
  • Dr. Mohamad Faris Mohamad Fathil Appointed as New Postgraduate Program Chairman of INEE

EVENTS & ACTIVITIES

  • Call for Paper IEEE International Conference on Sensor & Nanotechnology (SenNano2023)
  • Call for Papers 2022 Joint International Conference on Nanoscience & Nanoengineering (BOND 21 2022)
  • Trace Analysis and Biosensor International Symposium I: Emerging Challenges and Opportunities
  • CSR & STEM Programme: Exploration in The Nano World
  • Nanotechnology and Biosensor Colloquium 2019
Privacy Policy | Security Policy | Disclaimer | Sitemap | FAQ | Feedback | User Guide | Download | Postgraduate

Institute of Nano Electronic Engineering, Universiti Malaysia Perlis
Lot 106, 108 & 110, Blok A, Taman Pertiwi Indah,
Jalan Kangar-Alor Setar, Seriab 01000 Kangar, Perlis, Malaysia
Tel: +604-979 8581 Fax: +604-979 8578 Email: webmaster.inee@unimap.edu.my

Copyright © INEE UniMAP

  • Facebook
  • Instagram
  • Twitter
  • YouTube

For best view, please use latest version of Internet Explorer, Mozilla Firefox and Google Chrome with resolution 1280 x 768 and above.

QS 5 Stars

MQA

MSC Malaysia

myGov

Logo UniMAP

Visits 422 Total 190788

Designed by Mohd Isa from Portal Kerjaya & Sumber Informasi Malaysia