Institute of Nano Electronic Engineering

Universiti Malaysia Perlis

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Faradaic electrochemical impedimetric analysis on MoS2/Au-NPs decorated surface for C-reactive protein detection

December 7, 2022 By Editor

Abstract – Background: A label-free Faradaic electrochemical impedimetric was developed for a highly sensitive detection of C-reactive protein using a gold interdigitated microelectrode bio-sensing platform enhanced by a gold nanoparticle-decorated molybdenum disulfide (Au-NPs/MoS2) nanosheet via selected chemical linking processes. C-reactive protein (C-RP), a crystalline protein, generates by the liver and hikes when there is inflammation throughout the patients’ body. The concentrations of C-RP plasma levels tend to increase rapidly when the patient facing major injury which will lead to cardiovascular disease (CVD). Methods: The 5 µm microelectrode and gap size g-IDE with the nanostructured materials was demonstrated to increase the impedimetric detection response in Faradaic-mode electrochemical impedance spectroscopy high performance detection environment. The high surface area-to-volume ratio of the modified Au-NPs/MoS2 nanocomposite increased the probes loading onto the transducer and enhanced the impedimetric detection response of the C-RP target post-binding due to an amplified net change in the charge transfer resistance. The developed immunoassay revealed a linear detection of C-RP biomarker in a logarithmic-scale from as low as 1 fg/mL up to 1 µg/mL, and a limit of detection of 0.01 fg/mL. The sensor shows great potential as an early warning risk for cardiovascular disease at a threshold concentration value of C-RP at 1 µg/mL. Significant findings: The biosensor demonstrates an excellent discrimination against other competing proteins in serum, exhibiting the highest predilection to C-RP spiked human serum target. The sensor’s reproducibility is reported within an acceptable range of relative standard deviation of 1–4% for n = 3.

Corresponding Author: Assoc. Prof. Ir. Dr. Mohd Khairuddin Md Arshad
Corresponding Author’s Email: mohd.khairuddin@unimap.edu.my

Download Abstract: PDF
Link to Publication: https://doi.org/10.1016/j.jtice.2022.104450

Filed Under: Publications Tagged With: Biomarker, Biosensor, Impedance spectroscopy, Interdigitated microelectrode, Molybdenum disulfide

Current and future envision on developing biosensors aided by 2D molybdenum disulfide (MoS 2 ) productions

July 2, 2019 By Editor

Abstract – Two-dimensional (2D) layered nanomaterials have triggered an intensive interest due to the fascinating physiochemical properties with the exceptional physical, optical and electrical characteristics that transpired from the quantum size effect of their ultra-thin structure. Among the family of 2D nanomaterials, molybdenum disulfide (MoS 2 ) features distinct characteristics related to the existence of direct energy bandgap, which significantly lowers the leakage current and surpasses other 2D materials. In this overview, we expatiate the novel strategies to synthesize MoS 2 that cover techniques such as liquid exfoliation, chemical vapour deposition, mechanical exfoliation, hydrothermal reaction, and Van Der Waal epitaxial growth on the substrate. We extend the discussion on the recent progress in biosensing applications of the produced MoS 2 , highlighting the important surface-to-volume of ultrathin MoS 2 structure, which enhances the overall performance of the devices. Further, envisioned the missing piece with the current MoS 2 -based biosensors towards developing the future strategies.

Corresponding Author: Mohd Khairuddin Md Arshad
Corresponding Author’s Email: mohd.khairuddin@unimap.edu.my

Download: PDF

Filed Under: Publications Tagged With: 2D Materials, Biosensors, Label-based, Label-free, Molybdenum disulfide

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Institute of Nano Electronic Engineering, Universiti Malaysia Perlis
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