Editor, Author at Institute of Nano Electronic Engineering

Trace Analysis and Biosensor International Symposium I: Emerging Challenges and Opportunities

February 18, 2020 By Editor

The symposium was held for two days, from 10 to 11 February 2020 at Prince of Songkla University, Hat Yai, Thailand, with attendees coming from Thailand and international countries such as Japan, Korea, Taiwan and Malaysia. There were many activities in this symposium, including oral presentation from invited speakers, poster presentation from researchers and students. The topics of the symposium were related to technologies in trace analysis, sample preparation techniques, chromatography, optical sensors, biosensors, and electrochemical sensors. The opening ceremony presided by Professor Dr. Theerapol Srichana, Director of Research and Development, Prince of Songkla University.

List of INEE participants for the symposium on Trace Analysis and Biosensors:

Assoc. Prof. Dr. Mohammad Nuzaihan Md Nor – invited speaker
Assoc. Prof. Dr. Mohd Khairuddin Md Arshad – invited speaker
Dr. Voon Chun Hong
Dr. Liu Wei Wen
Dr. Mohamad Faris BIn Mohamad Fathil

Assoc. Prof. Dr. Ruslinda Appointed as New Director of NNC

December 24, 2019 By Editor

Fabrication of gold nanorod–zinc oxide nanocomposite on gap‑fingered integrated interdigitated aluminum electrodes and their response to electrolytes

December 5, 2019 By Editor

Abstract – This study describes the fabrication of three different gap-fingered aluminum-interdigitated electrodes (AlIDEs) on the silicon substrate based on photolithographic method, followed by integration of the gold nanorod–zinc oxide nanocomposite. The IDE masks were designed using AutoCAD software with the gaps of 10, 20, and 30 μm for design 1, 2, and 3, respectively. The morphological and electrical characterizations were subsequently performed using 3D-nanoprofiler, atomic force microscopy, high-power microscopy (HPM), scanning electron microscopy (SEM), and I–V. Validation of the fabricated surfaces (AlIDEs with/without gold nanorod–zinc oxide nanocomposite) against the electrolytes was performed at different pHs which are ranging from 1 to 12. SEM revealed the following gaps, 18.4, 20, and 40.5 μm for bare 1, 2, and 3, respectively. The measurements on I–V for bare AlIDEs indicated the electrolyte influences at different pH solutions, which were almost similar in terms of current variations except at highly acidic and alkaline. AlIDEs were well fabricated and the smaller the gap displayed the better the sensitivity, hence device 1 AlIDE has a good performance. Using different pH solutions which ranging from pH 1–12, before and after AlIDEs were coated with zinc oxide and gold nanorod. The responses of the devices were similar, fluctuating from highly acidic region to highly alkaline region in the cases of AlIDEs bare 1 and 3. Bare 2 AlIDE displayed similar responses with the AlIDE that was deposited with gold nanorod. With these results, we can conclude that deposition of gold nanorod on the device brought about the orderly response to the different pH and with the increment from acidic to alkaline increases, the proportional changes with the current were noticed.

Corresponding Author: Assoc. Prof. Dr. Subash C B Gopinath
Corresponding Author’s Email: subash@unimap.edu.my

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Co-ordinated split aptamer assembly and disassembly on Gold nanoparticle for functional detection of HIV-1 tat

September 22, 2019 By Editor

Abstract – Human immunodeficiency virus (HIV) is a life threatening, weakens the immune system upon infection, thus ultimately resulting in the fatal health issues. This situation necessitates the generation of different strategies for HIV detection. HIV-1 Tat, a transactivator of HIV gene expression, was chosen in this study as the target of a non-functional split aptamer. Implementation of split aptamer has been demonstrated in this work for colorimetric detection of HIV-1 Tat. An unmodified gold nanoparticle (GNP)-based colorimetric assay was used for the visible detection of the proof, displays color transitions from red to purple in relation to the dose-dependency of HIV-1 Tat against the split aptamer in ionic solutions. The visible color transition was characterized using UV–vis spectrophotometer showing spectrum shift and supported by Scanning Electron Microscopy observation. With addition of sodium chloride, the color of the solution started to change to purple and spectrum started to shift to higher wavelength due to aggregation at HIV-1 Tat concentration as low as 10 nM. Specificity test was conducted with duplexed split aptamer and HIV-1 p24 has shown slight color changes. With HIV-1 Nef, GNP solution retains the color similar to the control, which indicated the specific split aptamer interaction to HIV-1 Tat.

Corresponding Author: Ruslinda A. Rahim
Corresponding Author’s Email: ruslinda@unimap.edu.my

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