Editor, Author at Institute of Nano Electronic Engineering

A direct detection of human papillomavirus 16 genomic DNA using gold nanoprobes

December 8, 2016 By Editor

Abstract – Nanoparticles have been investigated as flagging tests for the sensitive DNA recognition that can be utilized as a part of field applications to defeat restrictions. Gold nanoparticles (AuNPs) have been widely utilized due to its optical property and capacity to get functionalized with a mixed bag of biomolecules. This study exhibits the utilization of AuNPs functionalized with single-stranded oligonucleotide (AuNP-oligo test) for fast the identification of Human Papillomavirus (HPV). This test is displayed on interdigitated electrode sensor and supported by colorimetric assay. DNA conjugated AuNP has optical property that can be controlled for the applications in diagnostics. With its identification abilities, this methodology incorporates minimal effort, strong reagents and basic identification of HPV.

Keywords – Colorimetric detection, DNA detection, Gold nanoparticles, Human Papillomavirus, Interdigitated electrode sensor

Corresponding Author: Uda Hashim
Corresponding Author’s Email: uda@unimap.edu.my

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INEE Wins Nanotechnology Innovation Research (PIN) Project Contest

October 26, 2016 By Editor

Institute of Nano Electronic Engineering (INEE) was recently crowned the winner of the National Nanotechnology Innovation Research (PIN) Project Contest 2016 at the Technology Park Malaysia in Kuala Lumpur.

National Nanotechnology Innovation Research (PIN) Project Contest 2016

The thesis entitled Electrical Detection of Dengue Virus (DENV) DNA Oligomer Using Silicon Nanowire Biosensor with Novel Molecular Gate Control penned by Dr. Mohammad Nuzaihan Md Nor from the Institute of Nano Electronic Engineering (INEE) caught the attention of the jury and won a cash prize of RM1,500, a trophy and a certificate.

The award ceremony was officiated by the Deputy Minister of the Ministry of Science, Technology and Innovation (MOSTI) Daturk Dr. Abu Bakar Mohamad Diah.

PIN was organised in conjunction with the National Nano Programme 2016 (NanoKEB 2016) which took place on 10 October 2016 to provide the opportunity for Master’s Degree and Doctorate Students with creative and innovative ideas to produce solution to problems such as energy and environment, healthcare and medicine, food and agriculture, and electronics and systems.

The contest was opened to Master’s Degree and Doctorate students registered with Malaysian public and private institutions of higher learning.

16 participants in the Doctorate category and 12 in the Master’s Degree category were assessed and selected to participate in the contest.

Formation of nanocrystalline GeSn thin film on Si substrate by sputtering and rapid thermal annealing

September 25, 2016 By Editor

Abstract – Nanocrystalline Ge1-xSnx thin films have been formed after rapid thermal annealing of sputtered GeSn layers. The alloy films were deposited onto the Silicon (100) substrate via low cost radio frequency magnetron sputtering. Then, the films were annealed by rapid thermal annealing at 350 °C, 400 °C, and 450 °C for 10 s. The morphological, structural, and optical properties of the layers were investigated with field emission scanning electron microscopy (FESEM), Energy-dispersive X-ray spectroscopy (EDX), Raman spectroscopy, and high-resolution X-ray diffraction (HR-XRD). The Raman analysis showed that the only observed phonon mode is attributed to Ge-Ge vibrations. Raman phonon intensities of GeSn thin films were enhanced with increasing the annealing temperature. The results clearly revealed that by increasing the annealing temperature the crystalline quality of the films were improved. The XRD measurements revealed the nanocrystalline phase formation in the annealed films with (111) preferred orientation. The results showed the potentiality of using the sputtering technique and rapid thermal anneal to produce crystalline GeSn layer.

Keywords – Germanium-tin, HR-XRD, Nanocrystalline materials, Raman spectroscopy, Sputtering, Thin films

Corresponding Author: Uda Hashim
Corresponding Author’s Email: uda@unimap.edu.my

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Official Visit by Malaysian Investment Development Authority (MIDA)

September 22, 2016 By Editor

Cell-targeting aptamers act as intracellular delivery vehicles

July 25, 2016 By Editor

Abstract – Aptamers are single-stranded nucleic acids or peptides identified from a randomized combinatorial library through specific interaction with the target of interest. Targets can be of any size, from small molecules to whole cells, attesting to the versatility of aptamers for binding a wide range of targets. Aptamers show drug properties that are analogous to antibodies, with high specificity and affinity to their target molecules. Aptamers can penetrate disease-causing microbial and mammalian cells. Generated aptamers that target surface biomarkers act as cell-targeting agents and intracellular delivery vehicles. Within this context, the “cell-internalizing aptamers” are widely investigated via the process of cell uptake with selective binding during in vivo systematic evolution of ligands by exponential enrichment (SELEX) or by cell-internalization SELEX, which targets cell surface antigens to be receptors. These internalizing aptamers are highly preferable for the localization and functional analyses of multiple targets. In this overview, we discuss the ways by which internalizing aptamers are generated and their successful applications. Furthermore, theranostic approaches featuring cell-internalized aptamers are discussed with the purpose of analyzing and diagnosing disease-causing pathogens.

Keywords – Aptamer, Internalization, Receptor, SELEX, Surface antigen

Corresponding Author: Subash C B Gopinath
Corresponding Author’s Email: subash@unimap.edu.my

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