Institute of Nano Electronic Engineering

Universiti Malaysia Perlis

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Fabrication of Silicon Nanowires Array Using E-beam Lithography Integrated with Microfluidic Channel for pH Sensing

March 25, 2015 By Editor

Abstract – Silicon nanowires based biosensors have garnered great potential in serving as highly sensitive, label-free and real-time response biosensing application. These biosensors are useful in detecting pH, DNA molecules, proteins and even single viruses. In this paper, we report the geometrical characteristics and performance of silicon nanowires array for pH level detection. The nanowires are designed for 40 nm, 50 nm and 60 nm diameter sizes. Top-Down Nanofabrication (TDN) is utilized in the development of resist mask and nanowires formation from silicon on insulator (SOI) wafer involving scanning electron microscope (SEM) based electron beam lithography (EBL). The smallest silicon nanowires structure achieved is 40 nm width and 30 nm height. The corresponding source and drain are fabricated via two aluminum (Al) electrodes on top of the silicon nanowires array using conventional lithography process. A 100 µm microfluidic channel is attached on the silicon nanowires for the sample solution transportation. pH level detection are performed based on several types of standard aqueous pH buffer solutions (pH 4, pH 7, pH 10 and pH 12) to test the electrical response of the sensor. Morphological and electrical responses have been proposed to verify the characteristics of the silicon nanowires array based pH sensor.

Keywords – Array, E-beam lithography, microfluidic channel, pH sensor, silicon nanowires

Corresponding Author: Mohd Khairuddin Md Arshad
Corresponding Author’s Email: mohd.khairuddin@unimap.edu.my

Full text: PDF

Filed Under: Publications Tagged With: Array, E-beam lithography, microfluidic channel, pH sensor, silicon nanowires

Evolutions of bonding wires used in semiconductor electronics: perspective over 25 years

March 25, 2015 By Editor

Abstract – The objective of this review is to study the evolution and key findings and critical technical challenges, solutions and future trend of bonding wires used in semiconductor electronics. Evolutions of bonding wires from Au to Cu and till the most recent silver (Ag) wire (perspective over 25 years packaging technology) have been discussed in this paper. The reliability performances of Au wire bonding, technical barriers of Cu wire bonding and corrosion mechanisms of Cu ball bonds are analyzed and covered. We focus on the influence of a variety of factors that have been reported recently, including reliability performance, wear out reliability performance that determine the selection of bonding wires to reach for developing high reliability of bonded devices. In the end of this review, the evolutions and future trends of bonding wires are compared and illustrated, which have marked
effect based on the materials properties as well as reliability of wire types.

Keywords – bonding wires, semiconductor electronics, packaging technology

Corresponding Author: Uda Hashim
Corresponding Author’s Email: uda@unimap.edu.my

Full text: PDF

Filed Under: Publications Tagged With: bonding wires, packaging technology, semiconductor electronics

A Portable Automatic Endpoint Detection System for Amplicons of Loop Mediated Isothermal Amplification on Microfluidic Compact Disk Platform

March 6, 2015 By Editor

Abstract – In recent years, many improvements have been made in foodborne pathogen detection methods to reduce the impact of food contamination. Several rapid methods have been developed with biosensor devices to improve the way of performing pathogen detection. This paper presents an automated endpoint detection system for amplicons generated by loop mediated isothermal amplification (LAMP) on a microfluidic compact disk platform. The developed detection system utilizes a monochromatic ultraviolet (UV) emitter for excitation of fluorescent labeled LAMP amplicons and a color sensor to detect the emitted florescence from target. Then it processes the sensor output and displays the detection results on liquid crystal display (LCD). The sensitivity test has been performed with detection limit up to 2.5 × 10−3 ng/µL with different DNA concentrations of Salmonella bacteria. This system allows a rapid and automatic endpoint detection which could lead to the development of a point-of-care diagnosis device for foodborne pathogens detection in a resource-limited environment.

Keywords – pathogen, Salmonella, food safety, diagnosis, LAMP, multiplexed detection, endpoint detection system, microfluidics, compact disc, lab-on-a-CD

Corresponding Author: Uda Hashim
Corresponding Author’s Email: uda@unimap.edu.my

Full text: PDF

Filed Under: Publications Tagged With: compact disc, diagnosis, endpoint detection system, food safety, lab-on-a-CD, LAMP, microfluidics, multiplexed detection, pathogen, Salmonella

Fabrication of Interdigitated Electrodes (IDE’s) by Conventional Photolithography Technique for pH Measurement Using Micro-Gap Structure

January 12, 2015 By Editor

Abstract – Micro interdigitated electrodes (IDE’s) have successfully been fabricated and characterized amperometrically for the electrochemical detection of the pH concentration and bio-molecules. In the present work, aluminium (Al) is used act as the metal contact (electrodes) deposited on the silicon substrate using a thermal evaporator (PVD) vacuum coater. The simple conventional photolithography was applied to fabricate the micro-gap capacitive transducer. IDE’s mask is designed using the aid of AutoCAD software for the detection of bio-substance which is an extremely small scale in size before being transferred to commercial chrome mask. The fabricated micro-gap sensor will then further evaluated through surface topology and electrical characteristic. The surface topology was implemented using AFM, LPM, SEM and HPM. The electrical measurements were carried out using a Dielectric analyzer (DA) with 2400 source meter (KEITHLEY) to examine the electrical characteristics such as capacitance and conductance. Purchased pH buffer solutions which varied from pH4 to pH 10 is dropped on the surface of microelectrode and the effect on it is investigated for the application in pH measurement. This study has proven that an increase in the concentration of acidic to alkaline pH leads to proportional to the capacitance.

Corresponding Author: Uda Hashim
Corresponding Author’s Email: uda@unimap.edu.my

Full text: PDF

Filed Under: Publications Tagged With: bio-molecules, electrochemical, ide

Fluorescence-Signaling Aptasensor for ATP and PDGF Detection on Functionalized Diamond Surface

January 2, 2015 By Editor

Abstract – An aminated diamond-based aptasensor is presented for adenosine triphosphate (ATP) and platelet-derived growth factor (PDGF) detection. In this work, a signal-off detection method was employed to provide a sensitive, selective and reusable platform for the simple detection of PDGF and ATP. The detection limit of 0.2 nMand 0.2 μMof PDGF and ATP were achieved, respectively. It was also demonstrated in this study that the aptasensor is selective for PDGF and ATP over other biomolecules. In addition, the reusability of the aptasensor was confirmed by performing multiple cycles, which shows that diamond is a promising candidate as a material for biosensor applications. Moreover, this detection system does not require a target label and it is unaffected by non-specific binding.

Corresponding Author: Ruslinda Abdul Rahim
Corresponding Author’s Email: ruslinda@unimap.edu.my

Full text: PDF

Filed Under: Publications Tagged With: adesnosine triphosphate, aptasensor, atp, pdgf, Platelet-derived growth factor

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