Institute of Nano Electronic Engineering

Universiti Malaysia Perlis

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The ZnO-FET Biosensor for Cardiac Troponin I

July 23, 2018 By Editor

Abstract – This paper investigates the influence of substrate-gate coupling on the ZnO-FET biosensor’s sensitivity for detection of cardiac troponin I (cTnI), a ‘gold standard’ biomarker for acute myocardial infarction (AMI). The FET-based device with introduction of substrate-gate coupling on p-type silicon-on-insulator (SOI) substrate is fabricated using conventional lithography processes. An n-type zinc oxide (ZnO) thin film deposited via electron-beam evaporator is used as transducer for bridging the source and drain regions. Surface modifications via functionalization with 3-aminopropyltriethoxysilane (APTES) and glutaraldehyde (GA) as chemical linkers, followed by immobilization of cTnI monoclonal antibody (MAb-cTnI) as bio-receptor on the ZnO thin film allow different concentration of cTnI detection with high selectivity. The device’s sensitivity increases up to 9 %•(g/ml)-1 with the increase of the substrate-gate voltage (VSG) up to -10 V at very low limit of detection (LOD) down to 1.6 fg/ml.

Corresponding Author: Mohamad Faris Mohamad Fathil
Corresponding Author’s Email: mohamadfaris@unimap.edu.my

Download: PDF

Filed Under: Publications Tagged With: Biosensors, Chemical modification, II-VI semiconductors, Lithography, Monoclonal antibodies, Silicon on insulator technology, Substrates, Thin films, Zinc oxide

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